Gene
kcnj10a
- ID
- ZDB-GENE-130726-1
- Name
- potassium inwardly rectifying channel subfamily J member 10a
- Symbol
- kcnj10a Nomenclature History
- Previous Names
-
- Kir4.1a (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables inward rectifier potassium channel activity. Acts upstream of or within kidney development; larval locomotory behavior; and swimming. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; opercular flap; pleuroperitoneal region; retinal inner nuclear layer; and scale. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31549 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 4 | Alliance | Enlarged vestibular aqueduct, digenic | 600791 |
| EAST syndrome | Alliance | SESAME syndrome | 612780 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| EAST syndrome | TL + MO1-kcnj10a | standard conditions | Mahmood et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR003268 | FPotassium channel, inwardly rectifying, Kir1.1 |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
| Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
Domain Details Per Protein
| Protein | Additional Resources | Length | FPotassium channel, inwardly rectifying, Kir1.1 | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FD27 | InterPro | 425 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnj10a-201
(1)
|
Ensembl | 1,263 nt | ||
| mRNA |
kcnj10a-202
(1)
|
Ensembl | 1,843 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-192C13 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003198888 (1) | 2561 nt | ||
| Genomic | GenBank:CU914532 (1) | 32325 nt | ||
| Polypeptide | UniProtKB:E7FD27 (1) | 425 aa |
- Comparative Orthology
- Alliance
- Della Vecchia, S., Ogi, A., Licitra, R., Abramo, F., Nardi, G., Mero, S., Landi, S., Battini, R., Sicca, F., Ratto, G.M., Santorelli, F.M., Marchese, M. (2022) Trehalose Treatment in Zebrafish Model of Lafora Disease. International Journal of Molecular Sciences. 23(12)
- Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021) Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(4):687-713
- Umans, R.A., Pollock, C., Mills, W.A., Clark, K.C., Pan, Y.A., Sontheimer, H. (2021) Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development. Frontiers in cell and developmental biology. 9:654338
- Chen, J., Poskanzer, K.E., Freeman, M.R., Monk, K.R. (2020) Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. 23(10):1297-1306
- Cozzolino, O., Sicca, F., Paoli, E., Trovato, F., Santorelli, F.M., Ratto, G.M., Marchese, M. (2020) Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging. Cells. 9(3):
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Silic, M.R., Wu, Q., Kim, B.H., Golling, G., Chen, K.H., Freitas, R., Chubykin, A.A., Mittal, S.K., Zhang, G. (2020) Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish. Genetics. 215(4):1067-1084
- Ranski, A.H., Kramer, A.C., Morgan, G.W., Perez, J.L., Thummel, R. (2018) Characterization of retinal regeneration in adult zebrafish following multiple rounds of phototoxic lesion. PeerJ. 6:e5646
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sicca, F., Ambrosini, E., Marchese, M., Sforna, L., Servettini, I., Valvo, G., Brignone, M.S., Lanciotti, A., Moro, F., Grottesi, A., Catacuzzeno, L., Baldini, S., Hasan, S., D'Adamo, M.C., Franciolini, F., Molinari, P., Santorelli, F.M., Pessia, M. (2016) Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. Scientific Reports. 6:34325
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