ZFIN is now using GRCz12tu for Genomic Data
Gene
tulp3
- ID
- ZDB-GENE-130530-714
- Name
- TUB like protein 3
- Symbol
- tulp3 Nomenclature History
- Previous Names
-
- zmp:0000000711
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within hepatocyte homeostasis and renal tubule development. Predicted to be located in cilium and plasma membrane. Is expressed in several structures, including digestive system; eye; heart; integument; and pleuroperitoneal region. Used to study ciliopathy. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human TULP3 (TUB like protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hepatorenocardiac degenerative fibrosis | 619902 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO3-tulp3 | standard conditions | Epting et al., 2025 |
| ciliopathy | tulp3uf3/uf3 | standard conditions | Epting et al., 2025 |
| ciliopathy | WT + MO2-tulp3 | standard conditions | Epting et al., 2025 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tubby, C-terminal | Tubby, C-terminal, conserved site | Tubby-like, C-terminal | Tubby, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:F1R8G2 | InterPro | 510 | ||||
| UniProtKB:A0A8M2BBP8 | InterPro | 490 | ||||
| UniProtKB:A0A8M2BBL9 | InterPro | 454 | ||||
| UniProtKB:A0AC58J8Y0 | InterPro | 454 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance