Gene

shank1

ID

ZDB-GENE-130530-691

Name

SH3 and multiple ankyrin repeat domains 1

Symbol

shank1 Nomenclature History

Previous Names

si:dkey-105i19.4
zmp:0000000688 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have GKAP/Homer scaffold activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of synaptic transmission; and regulation of AMPA receptor activity. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With shank1 Human Ortholog

No data available

Associated With shank1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR032425	Talin, N-terminal F0 domain
Domain	IPR041489	PDZ domain 6
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	PDZ domain	PDZ domain 6	PDZ superfamily	SH3 domain	SH3-like domain superfamily	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily	Talin, N-terminal F0 domain
UniProtKB:A0A8M9PQF3 InterPro	882
UniProtKB:A0A8M9PRS2 InterPro	2469
UniProtKB:A0A8M9Q8Y1 InterPro	1807
UniProtKB:A0A8M9PJG1 InterPro	883
UniProtKB:A0A8M9Q129 InterPro	2449
UniProtKB:A0A8M9PEY7 InterPro	2467
UniProtKB:A0A8M9P8G4 InterPro	1773
UniProtKB:A0A8M9PQE5 InterPro	2461

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	shank1-201 (1) Ensembl	Havana	2865 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations