Gene
jag2a
- ID
- ZDB-GENE-130530-549
- Name
- jagged canonical Notch ligand 2a
- Symbol
- jag2a Nomenclature History
- Previous Names
-
- zmp:0000000546 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity and calcium ion binding activity. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in membrane. Is expressed in ectoderm; ionocyte progenitor cell; pronephros; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Muscular dystrophy, limb-girdle, autosomal recessive 27 | 619566 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Family | IPR026219 | Jagged/Serrate protein |
| Family | IPR050906 | Notch signaling pathway |
| Family | IPR051022 | Notch Signaling and Cell Fate Determination |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Jagged/Serrate protein | Notch ligand, N-terminal domain | Notch Signaling and Cell Fate Determination | Notch signaling pathway | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QVB9
|
1136 | ||||||||||||
|
UniProtKB:A0A8N7TDN4
|
1230 | ||||||||||||
|
UniProtKB:A0A8M2B354
|
1192 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance