Gene
jag2a
- ID
- ZDB-GENE-130530-549
- Name
- jagged canonical Notch ligand 2a
- Symbol
- jag2a Nomenclature History
- Previous Names
-
- zmp:0000000546 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Predicted to be involved in animal organ development; cell differentiation; and system development. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in membrane. Is expressed in ectoderm; ionocyte progenitor cell; pronephros; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive limb-girdle muscular dystrophy type 27 | Alliance | Muscular dystrophy, limb-girdle, autosomal recessive 27 | 619566 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Family | IPR026219 | Jagged/Serrate protein |
| Family | IPR051022 | Notch Signaling and Cell Fate Determination |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Jagged/Serrate protein | Notch ligand, N-terminal domain | Notch Signaling and Cell Fate Determination | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QVB9 | InterPro | 1136 | |||||||||||
| UniProtKB:A0A8N7TDN4 | InterPro | 1230 | |||||||||||
| UniProtKB:A0A8M2B354 | InterPro | 1192 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance