ZFIN is now using GRCz12tu for Genomic Data
Gene
dlc1
- ID
- ZDB-GENE-130206-12
- Name
- DLC1 Rho GTPase activating protein
- Symbol
- dlc1 Nomenclature History
- Previous Names
-
- unm_sa1141
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTPase activator activity and lipid binding activity. Predicted to be involved in signal transduction. Predicted to be located in focal adhesion; lipid droplet; and mitochondrial membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR002913 | START domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR023393 | START-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Rho GTPase-activating protein domain | Rho GTPase activation protein | START domain | START-like domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FBY0 | InterPro | |||||||
| UniProtKB:A0A8M9PK49 | InterPro | 1191 | ||||||
| UniProtKB:A0A8M6Z677 | InterPro | 1669 | ||||||
| UniProtKB:A0AC58JHT8 | InterPro | 1669 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance