Gene

crispld2

ID

ZDB-GENE-130131-1

Name

cysteine-rich secretory protein LCCL domain containing 2

Symbol

crispld2 Nomenclature History

Previous Names

zmp:0000001254

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Acts upstream of or within face morphogenesis; roof of mouth development; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in head and pharynx. Used to study orofacial cleft. Orthologous to human CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With crispld2 Human Ortholog

No data available

Associated With crispld2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
orofacial cleft	WT + MO3-crispld2	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018244	Allergen V5/Tpx-1-related, conserved site
Domain	IPR004043	LCCL domain
Domain	IPR014044	CAP domain
Family	IPR001283	Cysteine-rich secretory protein-related
Family	IPR051957	Cysteine-rich secretory LCCL domain-containing protein
Homologous_superfamily	IPR035940	CAP superfamily
Homologous_superfamily	IPR036609	LCCL domain superfamily

Domain Details Per Protein

Protein	Length	Allergen V5/Tpx-1-related, conserved site	CAP domain	CAP superfamily	Cysteine-rich secretory LCCL domain-containing protein	Cysteine-rich secretory protein-related	LCCL domain	LCCL domain superfamily
UniProtKB:F1QW68 InterPro	512
UniProtKB:A0A8M1RM30 InterPro	508

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	crispld2-201 (1) Ensembl	Ensembl		1,539 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-crispld2		crispld2		Rabbit	IHC WB		2

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations