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ZIRC
ZFIN ID: ZDB-GENE-130129-1
Gene Name: low density lipoprotein receptor-related protein 4
Gene Symbol: lrp4    Nomenclature History

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Previous Names: eni, nui

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Unmapped
Description: Predicted to have calcium ion binding activity. Involved in axon regeneration; establishment of synaptic specificity at neuromuscular junction; and neuromuscular synaptic transmission. Predicted to localize to the integral component of membrane. Used to study bone development disease. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Is expressed in several structures, including actinotrichium; adaxial cell; caudal vein plexus; median fin fold; and nervous system. Orthologous to human LRP4 (LDL receptor related protein 4).
Genome Resources: Alliance (1),  Gene:110351181 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi36 Point Mutation Unknown Premature Stop ENU
p184 Small Deletion Exon 9 Frameshift, Premature Stop TALEN
p185 Indel Exon 9 Frameshift, Premature Stop TALEN
sa15807 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lrp4 N/A 1
    MO2-lrp4 N/A 1
    TALEN1-lrp4 2
    DISEASE ASSOCIATED WITH lrp4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cenani-Lenz syndactyly syndrome Alliance Cenani-Lenz syndactyly syndrome 212780
    congenital myasthenic syndrome 17 Alliance ?Myasthenic syndrome, congenital, 17 616304
    sclerosteosis 2 Alliance Sclerosteosis 2 614305
    DISEASE ASSOCIATED WITH lrp4 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    bone development disease AB + MO1-lrp4 control Tian et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon regeneration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 6)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lrp4 monoclonal Mouse IHC Abcam plc
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrp4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actc1b:lrp4-GFP) actc1b GFPlrp4 Danio rerio 1 2
    Tg(mnx1:lrp4-GFP) mnx1 GFPlrp4 Danio rerio 1 2
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001351714 (1)
    Genomic GenBank:FO834870 (1) 36691 bp
    Select Tool
    Polypeptide UniProtKB:A0A386NG17 (1) 1897 aa
    Sequence Clusters UniGene:115613 (1)
    Sequence Information (all 25)
    ORTHOLOGY for lrp4 ( Unmapped )
    CITATIONS (19)