Gene

lrp4

ID
ZDB-GENE-130129-1
Name
low density lipoprotein receptor-related protein 4
Symbol
lrp4 Nomenclature History
Previous Names
  • eni
  • nui
Type
protein_coding_gene
Location
Unmapped
Description
Predicted to have calcium ion binding activity. Involved in axon regeneration; establishment of synaptic specificity at neuromuscular junction; and neuromuscular synaptic transmission. Predicted to localize to integral component of membrane. Is expressed in several structures, including actinotrichium; adaxial cell; caudal vein plexus; median fin fold; and nervous system. Used to study bone development disease. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lrp4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cenani-Lenz syndactyly syndrome Alliance Cenani-Lenz syndactyly syndrome 212780
congenital myasthenic syndrome 17 Alliance ?Myasthenic syndrome, congenital, 17 616304
sclerosteosis 2 Alliance Sclerosteosis 2 614305
Associated With lrp4 Via Experimental Models
Human Disease Fish Conditions Citations
bone development disease AB + MO1-lrp4 control Tian et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR026823 Complement Clr-like EGF domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR036055 LDL receptor-like superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement Clr-like EGF domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Six-bladed beta-propeller, TolB-like
UniProtKB:A0A2R8PYI8 968
UniProtKB:A0A386NG17 1897
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-lrp4 monoclonal Mouse
  • IHC
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Citations