Gene

nfkb1

ID
ZDB-GENE-121204-3
Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Symbol
nfkb1 Nomenclature History
Previous Names
  • p50 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to several human genes including BICDL1 (BICD family like cargo adaptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfkb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency, common variable, 12 616576
Associated With nfkb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030492 Rel homology domain, conserved site
Domain IPR002909 IPT domain
Domain IPR011539 Rel homology domain (RHD), DNA-binding domain
Domain IPR032397 Rel homology dimerisation domain
Domain IPR033926 NFkappaB IPT domain
Family IPR000451 NF-kappa-B/Dorsal
Family IPR030503 Nuclear factor NF-kappa-B, p105 subunit
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain NF-kappa-B/Dorsal NFkappaB IPT domain Nuclear factor NF-kappa-B, p105 subunit p53-like transcription factor, DNA-binding Rel homology dimerisation domain Rel homology domain, conserved site Rel homology domain (RHD), DNA-binding domain Rel homology domain (RHD), DNA-binding domain superfamily
UniProtKB:A0A0R4IN79 540
UniProtKB:Q4PLU8 85
UniProtKB:A0A0R4ICP8 282
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations