dennd4c

ID

ZDB-GENE-120727-13

Name

DENN/MADD domain containing 4C

Symbol

dennd4c Nomenclature History

Previous Names

unm_sa1910

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus and regulation of Rab protein signal transduction. Predicted to be located in cytoplasm. Predicted to be part of ESCRT I complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND4C (DENN domain containing 4C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dennd4c Human Ortholog

No data available

Associated With dennd4c Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001194	cDENN domain
Domain	IPR005112	dDENN domain
Domain	IPR005113	uDENN domain
Domain	IPR023341	MABP domain
Domain	IPR037516	Tripartite DENN domain
Family	IPR018798	Multivesicular body subunit 12
Family	IPR051696	DENN Domain-Containing GEFs
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR043153	DENN domain, C-terminal lobe
Repeat	IPR002885	Pentatricopeptide repeat