Gene
tac3b
- ID
- ZDB-GENE-120716-1
- Name
- tachykinin precursor 3b
- Symbol
- tac3b Nomenclature History
- Previous Names
-
- tac2b (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be involved in positive regulation of blood pressure. Predicted to act upstream of or within tachykinin receptor signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including adipose tissue; brain; liver; pleuroperitoneal region; and retina. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 10 with or without anosmia. Orthologous to human TAC3 (tachykinin precursor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Li et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3620 | Allele with one deletion | Exon 3 | Unknown | TALEN |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 10 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 10 with or without anosmia | 614839 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Neurokinin-B/Tachykinin-3 | Tachykinin/Neurokinin-like, conserved site |
|---|---|---|---|---|
| UniProtKB:A0A8M2BDL5 | InterPro | 173 | ||
| UniProtKB:H2D7E9 | InterPro | 115 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-41G7 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256390 (1) | 626 nt | ||
| Genomic | GenBank:BX323816 (1) | 190532 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDL5 (1) | 173 aa |
- Li, Y., Zhao, T., Liu, Y., Lin, H., Li, S., Zhang, Y. (2021) Knockout of tac3 Genes in Zebrafish Shows No Impairment of Reproduction. General and comparative endocrinology. 311:113839
- Trivellin, G., Tirosh, A., Hernández-Ramírez, L.C., Gupta, T., Tsai-Morris, C.H., Faucz, F.R., Burgess, H.A., Feldman, B., Stratakis, C.A. (2020) The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish. Molecular and Cellular Endocrinology. 520:111091
- London, S., Volkoff, H. (2019) Effects of fasting on the central expression of appetite-regulating and reproductive hormones in wild-type and Casper zebrafish (Danio rerio). General and comparative endocrinology. 282:113207
- Qi, X., Salem, M., Zhou, W., Sato-Shimizu, M., Ye, G., Smitz, J., Peng, C. (2016) Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production. Endocrinology. 157:3355-65
- Hu, G., Lin, C., He, M., Wong, A.O. (2014) Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish. General and comparative endocrinology. 208:94-108
- López-Bellido, R., Barreto-Valer, K., and Rodríguez, R.E. (2013) Substance P mRNA expression during zebrafish development: Influence of mu opioid receptor and cocaine. Neuroscience. 242:53-68
- Biran, J., Palevitch, O., Ben-Dor, S., and Levavi-Sivan, B. (2012) Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction. Proceedings of the National Academy of Sciences of the United States of America. 109(26):10269-10274
- Ogawa, S., Ramadasan, P.N., Goschorska, M., Anantharajah, A., Ng, K.W., and Parhar, I.S. (2012) Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish. The Journal of comparative neurology. 520(13):2991-3012
- Zhou, W., Li, S., Liu, Y., Qi, X., Chen, H., Cheng, C.H., Liu, X., Zhang, Y., and Lin, H. (2012) The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio). Molecular and Cellular Endocrinology. 361(1-2):202-212
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