Gene
ptgir
- ID
- ZDB-GENE-120511-1
- Name
- prostaglandin I2 receptor
- Symbol
- ptgir Nomenclature History
- Previous Names
-
- PRS1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables prostacyclin receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell proliferation; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Orthologous to human PTGIR (prostaglandin I2 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tsuge et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nijoukubo et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35812 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ptgir | N/A | Nijoukubo et al., 2016 |
| MO2-ptgir | N/A | Nijoukubo et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Prostacyclin (prostanoid IP) receptor | Prostanoid receptor |
|---|---|---|---|---|---|---|
| UniProtKB:E7FE45 | InterPro | 364 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-242K11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-202G17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_684811 (1) | 8746 nt | ||
| Genomic | GenBank:CR925772 (1) | 174305 nt | ||
| Polypeptide | UniProtKB:E7FE45 (1) | 364 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Sheng, J., Meng, Q., Yang, Z., Guan, J., Zhao, Y., Zhang, J., Wang, Y., Zhao, L., Wang, Y. (2020) Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade. Phytomedicine : international journal of phytotherapy and phytopharmacology. 76:153263
- Li, Y.F., Canário, A.V.M., Power, D.M., Campinho, M.A. (2019) Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish. Environment International. 124:511-520
- Nijoukubo, D., Tanaka, Y., Okuno, Y., Yin, G., Kitazawa, T., Peterson, R.E., Kubota, A., Teraoka, H. (2016) Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish. Chemosphere. 156:111-117
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tsuge, K., Iwasaki, R., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y. (2013) Molecular and pharmacological characterization of zebrafish 'relaxant' prostanoid receptors. Biochemical and Biophysical Research Communications. 436(4):685-90
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