Gene
rasip1
- ID
- ZDB-GENE-120403-3
- Name
- Ras interacting protein 1
- Symbol
- rasip1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable GTPase binding activity. Acts upstream of or within cell-cell junction organization and sprouting angiogenesis. Predicted to be active in cell-cell junction. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Orthologous to human RASIP1 (Ras interacting protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
1 - 8 of 8
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dilute domain | Ras-associating domain | Rasip1/Radil, cargo-binding domain | SMAD/FHA domain superfamily | Ubiquitin-like domain superfamily | Vascular development regulator domain-containing protein |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F6P4 | InterPro | 989 | ||||||
| UniProtKB:J9PJE8 | InterPro | 989 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rasip1-201
(1)
|
Ensembl | 2,970 nt | ||
| mRNA |
rasip1-202
(1)
|
Ensembl | 3,613 nt |
1 - 2 of 2
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-rasip1 | polyclonal | Rabbit |
|
1 |
1 - 1 of 1
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-70L21 |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001289880 (1) | 2970 nt | ||
| Genomic | GenBank:CU694256 (1) | 99030 nt | ||
| Polypeptide | UniProtKB:E7F6P4 (1) | 989 aa |
- Lee, M., Betz, C., Yin, J., Paatero, I., Schellinx, N., Carte, A.N., Wilson, C.W., Ye, W., Affolter, M., Belting, H.G. (2021) Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1. Development (Cambridge, England). 148(15):
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wilson, C.W., Parker, L.H., Hall, C.J., Smyczek, T., Mak, J., Crow, A., Posthuma, G., De Mazière, A., Sagolla, M., Chalouni, C., Vitorino, P., Roose-Girma, M., Warming, S., Klumperman, J., Crosier, P.S., and Ye, W. (2013) Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood. 122(22):3678-90
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
1 - 5 of 5
Show