Gene
ube2d2
- ID
- ZDB-GENE-120312-1
- Name
- ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
- Symbol
- ube2d2 Nomenclature History
- Previous Names
-
- zgc:55886
- zgc:77149
- zmp:0000000618 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin conjugating enzyme activity. Acts upstream of or within negative regulation of smoothened signaling pathway. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55886 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Pan et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ube2d2 | N/A | Pan et al., 2017 |
| MO2-ube2d2 | N/A | Pan et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ubiquitin-conjugating enzyme, active site | Ubiquitin-conjugating enzyme E2, catalytic core domain | Ubiquitin-conjugating enzyme/RWD-like |
|---|---|---|---|---|---|
| UniProtKB:Q7ZUK1 | InterPro | 147 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ube2d2-201
(1)
|
Ensembl | 1,992 nt | ||
| mRNA |
ube2d2-202
(1)
|
Ensembl | 1,246 nt | ||
| mRNA |
ube2d2-203
(1)
|
Ensembl | 450 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-345I5 | ||
| Contained in | Fosmid | CH1073-253L17 | ||
| Encodes | cDNA | MGC:55886 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77149 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192124 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200959 (1) | 1825 nt | ||
| Genomic | GenBank:CU570692 (1) | 88680 nt | ||
| Polypeptide | UniProtKB:Q7ZUK1 (1) | 147 aa |
- Comparative Orthology
- Alliance
- Pan, C., Xiong, Y., Lv, X., Xia, Y., Zhang, S., Chen, H., Fan, J., Wu, W., Liu, F., Wu, H., Zhou, Z., Zhang, L., Zhao, Y. (2017) UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO reports. 18:1922-1934
- Wang, L., Ma, X., Xu, X., Zhang, Y. (2017) Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish. Scientific Reports. 7:1250
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Salisbury, J.P., Sîrbulescu, R.F., Moran, B.M., Auclair, J.R., Zupanc, G.K., Agar, J.N. (2015) The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation. BMC Genomics. 16:166
- Biacchesi, S., Merour, E., Lamoureux, A., Bernard, J., and Bremont, M. (2012) Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I. PLoS One. 7(10):e47737
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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