Gene
map3k14a
- ID
- ZDB-GENE-120215-80
- Name
- mitogen-activated protein kinase kinase kinase 14a
- Symbol
- map3k14a Nomenclature History
- Previous Names
-
- si:dkey-260c8.4
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade and canonical NF-kappaB signal transduction. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 112 | Alliance | Immunodeficiency 112 | 620449 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitogen-activated protein kinase kinase kinase | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:E7FEY1 | InterPro | 825 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k14a-201
(1)
|
Ensembl | 2,846 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance