Gene
oxtrb
- ID
- ZDB-GENE-110805-1
- Name
- oxytocin receptor b
- Symbol
- oxtrb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables peptide hormone binding activity. Acts upstream of or within social behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in alcohol dependence; depressive disorder; impulse control disorder; personality disorder; and substance abuse (multiple). Orthologous to human OXTR (oxytocin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chou et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gemmer et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Oxytocin receptor | Vasopressin receptor |
|---|---|---|---|---|---|---|
| UniProtKB:E4W698 | InterPro | 382 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Naderi, M., Nguyen, T.M.N., Pompili, C., Kwong, R.W.M. (2024) Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions. Frontiers in molecular neuroscience. 17:14832381483238
- Akinrinade, I., Kareklas, K., Teles, M.C., Reis, T.K., Gliksberg, M., Petri, G., Levkowitz, G., Oliveira, R.F. (2023) Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish. Science (New York, N.Y.). 379:123212371232-1237
- Liu, Z., Tan, S., Zhou, L., Chen, L., Liu, M., Wang, W., Tang, Y., Yang, Q., Chi, S., Jiang, P., Zhang, Y., Cui, Y., Qin, J., Hu, X., Li, S., Liu, Q., Chen, L., Li, S., Burstein, E., Li, W., Zhang, X., Mo, X., Jia, D. (2023) SCGN deficiency is a risk factor for autism spectrum disorder. Signal transduction and targeted therapy. 8:33
- Gemmer, A., Mirkes, K., Anneser, L., Eilers, T., Kibat, C., Mathuru, A., Ryu, S., Schuman, E. (2022) Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Scientific Reports. 12:4322
- Chuang, H.J., Chang, C.Y., Ho, H.P., Chou, M.Y. (2021) Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish. International Journal of Molecular Sciences. 22(14):
- Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., Westberg, L. (2020) Oxytocin Receptors Regulate Social Preference in Zebrafish. Scientific Reports. 10:5435
- Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238
- Daza, D.O., Lewicka, M., and Larhammar, D. (2012) The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes. General and comparative endocrinology. 175(1):135-143
- Chou, M.Y., Hung, J.C., Wu, L.C., Hwang, S.P., and Hwang, P.P. (2011) Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation. Cellular and molecular life sciences : CMLS. 68(16):2797-809
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