Gene

znfx1

ID

ZDB-GENE-110804-2

Name

zinc finger, NFX1-type containing 1

Symbol

znfx1 Nomenclature History

Previous Names

fb60c02
si:zfos-1537b9.1
wu:fb60c02

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Predicted to be involved in chromatin silencing at centromere and chromatin silencing by small RNA. Predicted to localize to nuclear RNA-directed RNA polymerase complex. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Diotel et al., 2015

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With znfx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 91 and hyperinflammation	619644

Associated With znfx1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000967	Zinc finger, NF-X1-type
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR041677	DNA2/NAM7 helicase, helicase domain
Domain	IPR041679	DNA2/NAM7 helicase-like, C-terminal
Domain	IPR046439	Zinc finger, RZ-type
Domain	IPR047187	Upf1-like, C-terminal helicase domain
Family	IPR045055	DNA2/NAM7-like helicase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	DNA2/NAM7 helicase, helicase domain	DNA2/NAM7 helicase-like, C-terminal	DNA2/NAM7-like helicase	P-loop containing nucleoside triphosphate hydrolase	Upf1-like, C-terminal helicase domain	Zinc finger, NF-X1-type	Zinc finger, RZ-type
UniProtKB:A0A8M9PND3 InterPro	2018

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	znfx1-201 (1) Ensembl	Ensembl		3,072 nt	Select Tool ZFIN BLAST
mRNA	znfx1-202 (1) Ensembl	Ensembl		4,353 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations