Gene
ago2
- ID
- ZDB-GENE-110606-6
- Name
- argonaute RISC catalytic component 2
- Symbol
- ago2 Nomenclature History
- Previous Names
-
- Ago2 (1)
- eif2c2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Exhibits miRNA binding activity and pre-miRNA binding activity. Involved in nucleate erythrocyte differentiation and pre-miRNA processing. Predicted to localize to P-body; RISC complex; and mRNA cap binding activity complex. Is expressed in several structures, including eye; fin; integument; intermediate cell mass of mesoderm; and pleuroperitoneal region. Orthologous to human AGO2 (argonaute RISC catalytic component 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Lessel-Kreienkamp syndrome | 619149 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003100 | PAZ domain |
Domain | IPR003165 | Piwi domain |
Domain | IPR014811 | Argonaute, linker 1 domain |
Domain | IPR032472 | Argonaute linker 2 domain |
Domain | IPR032473 | Protein argonaute, Mid domain |
Domain | IPR032474 | Protein argonaute, N-terminal |
Domain | IPR045246 | Argonaute-like, PIWI domain |
Family | IPR028602 | Protein argonaute-2 |
Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
Homologous_superfamily | IPR036085 | PAZ domain superfamily |
Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
Domain Details Per Protein
Protein | Length | Argonaute-like, PIWI domain | Argonaute, linker 1 domain | Argonaute linker 2 domain | PAZ domain | PAZ domain superfamily | Piwi domain | Protein argonaute-2 | Protein argonaute, Mid domain | Protein argonaute, N-terminal | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3AKD0
|
898 | |||||||||||
UniProtKB:K4I874
|
873 |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance