Gene
spock1
- ID
- ZDB-GENE-110428-1
- Name
- SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
- Symbol
- spock1 Nomenclature History
- Previous Names
-
- im:7158540
- si:dkey-201i24.6
- zmp:0000000756
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Acts upstream of or within establishment of blood-brain barrier. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in basal plate midbrain region and nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158540 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from O'Brown et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hm41 | Allele with multiple variants | Unknown | Unknown | spontaneous | |
| hm43 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hm44Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa9838 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19073 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa28231 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-hand domain pair | Kazal domain | Kazal domain superfamily | SPARC/Testican, calcium-binding domain | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2L032 | InterPro | |||||||
| UniProtKB:A0A0G2KM32 | InterPro | |||||||
| UniProtKB:E7F9M2 | InterPro | 355 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spock1-201
(1)
|
Ensembl | 1,567 nt | ||
| mRNA |
spock1-202
(1)
|
Ensembl | 271 nt | ||
| mRNA |
spock1-203
(1)
|
Ensembl | 1,934 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-201I24 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7158540 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021481084 (1) | |||
| Genomic | GenBank:CU468924 (1) | 159932 nt | ||
| Polypeptide | UniProtKB:E7F9M2 (2) | 355 aa |
- Comparative Orthology
- Alliance
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Silva, I. A. L., Conceição, N., Michou, L., Cancela, M. L. (2014) Can zebrafish be a valid model to study Paget's disease of bone?. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):678-688
- Renn, J., Schaedel, M., Volff, J.N., Goerlich, R., Schartl, M., and Winkler, C. (2006) Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene. 372:208-218
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