Gene
thbd
- ID
- ZDB-GENE-110411-281
- Name
- thrombomodulin
- Symbol
- thbd Nomenclature History
- Previous Names
-
- si:ch1073-471m19.4
- TM-a (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Predicted to act upstream of or within blood coagulation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lee et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombophilia due to thrombomodulin defect | Alliance | Thrombophilia 12 due to thrombomodulin defect | 614486 |
| {Hemolytic uremic syndrome, atypical, susceptibility to, 6} | 612926 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M6Z2V7 | InterPro | 515 |
| UniProtKB:A0AB32TB02 | InterPro | 515 |
Interactions and Pathways
No data available
Plasmids
No data available