Gene
fyco1a
- ID
- ZDB-GENE-110411-276
- Name
- FYVE and coiled-coil domain autophagy adaptor 1a
- Symbol
- fyco1a Nomenclature History
- Previous Names
-
- si:ch73-217b7.5
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity. Predicted to be involved in plus-end-directed vesicle transport along microtubule and positive regulation of autophagosome maturation. Predicted to localize to autophagosome; late endosome; and lysosome. Human ortholog(s) of this gene implicated in cataract 18. Orthologous to human FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 18 | Alliance | Cataract 18, autosomal recessive | 610019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000306 | FYVE zinc finger |
| Domain | IPR004012 | RUN domain |
| Domain | IPR009038 | GOLD domain |
| Domain | IPR017455 | Zinc finger, FYVE-related |
| Domain | IPR047336 | FYCO1, RUN domain |
| Domain | IPR047337 | FYCO1, FYVE domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036598 | GOLD domain superfamily |
| Homologous_superfamily | IPR037213 | RUN domain superfamily |
Domain Details Per Protein
| Protein | Length | FYCO1, FYVE domain | FYCO1, RUN domain | FYVE zinc finger | GOLD domain | GOLD domain superfamily | RUN domain | RUN domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, FYVE-related | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z4L1
|
1178 | ||||||||||
|
UniProtKB:A0A8M3B6E4
|
1497 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fyco1a-201
(1)
|
Ensembl | 268 nt | ||
| mRNA |
fyco1a-202
(1)
|
Ensembl | 4,952 nt |
Interactions and Pathways
No data available
Plasmids
No data available