Gene

capn10

ID

ZDB-GENE-110411-137

Name

calpain 10

Symbol

capn10 Nomenclature History

Previous Names

si:ch73-216b13.1 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human CAPN10 (calpain 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With capn10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, noninsulin-dependent 1}	601283

Associated With capn10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Domain	IPR001300	Peptidase C2, calpain, catalytic domain
Domain	IPR022682	Peptidase C2, calpain, large subunit, domain III
Domain	IPR022683	Peptidase C2, calpain, domain III
Family	IPR022684	Peptidase C2, calpain family
Homologous_superfamily	IPR036213	Calpain large subunit, domain III superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Calpain large subunit, domain III superfamily	Cysteine peptidase, cysteine active site	Papain-like cysteine peptidase superfamily	Peptidase C2, calpain, catalytic domain	Peptidase C2, calpain, domain III	Peptidase C2, calpain family	Peptidase C2, calpain, large subunit, domain III
UniProtKB:A0A8N7UW33 InterPro	649

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	capn10-201 (1) Ensembl	Ensembl	1,977 nt	Select Tool ZFIN BLAST
mRNA	capn10-202 (1) Ensembl	Ensembl	2,684 nt	Select Tool ZFIN BLAST
mRNA	capn10-203 (1) Ensembl	Ensembl	421 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations