ZFIN is now using GRCz12tu for Genomic Data
Gene
lig1
- ID
- ZDB-GENE-110404-2
- Name
- ligase I, DNA, ATP-dependent
- Symbol
- lig1 Nomenclature History
- Previous Names
-
- si:dkeyp-35b8.5
- si:dkeyp-35b8.7
- wu:fc54a11
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA ligase (ATP) activity. Predicted to be involved in Okazaki fragment processing involved in mitotic DNA replication. Predicted to act upstream of or within DNA damage response; DNA metabolic process; and cell division. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 96; inherited metabolic disorder; and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 96 | Alliance | Immunodeficiency 96 | 619774 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016059 | DNA ligase, ATP-dependent, conserved site |
| Domain | IPR012308 | DNA ligase, ATP-dependent, N-terminal |
| Domain | IPR012309 | DNA ligase, ATP-dependent, C-terminal |
| Domain | IPR012310 | DNA ligase, ATP-dependent, central |
| Family | IPR000977 | DNA ligase, ATP-dependent |
| Family | IPR050191 | ATP-dependent DNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR036599 | DNA ligase, ATP-dependent, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent DNA ligase | DNA ligase, ATP-dependent | DNA ligase, ATP-dependent, central | DNA ligase, ATP-dependent, conserved site | DNA ligase, ATP-dependent, C-terminal | DNA ligase, ATP-dependent, N-terminal | DNA ligase, ATP-dependent, N-terminal domain superfamily | Nucleic acid-binding, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S533 | InterPro | 1058 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers