Gene

slc4a1b

ID
ZDB-GENE-110215-2
Name
solute carrier family 4 member 1b (Diego blood group)
Symbol
slc4a1b Nomenclature History
Previous Names
  • zAE1b (1)
  • pers
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits anion:anion antiporter activity and bicarbonate transmembrane transporter activity. Involved in calcium ion import. Predicted to localize to basolateral plasma membrane. Is expressed in ball; gill; ionocyte; and sensory system. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc4a1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spherocytosis type 4 Alliance Spherocytosis, type 4 612653
Cryohydrocytosis 185020
Distal renal tubular acidosis 1 179800
Distal renal tubular acidosis 4 with hemolytic anemia 611590
Ovalocytosis, SA type 166900
[Blood group, Diego] 110500
[Blood group, Froese] 601551
[Blood group, Swann] 601550
[Blood group, Waldner] 112010
[Blood group, Wright] 112050
[Malaria, resistance to] 611162
Associated With slc4a1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018241 Anion exchange, conserved site
Domain IPR011531 Bicarbonate transporter, C-terminal
Domain IPR013769 Band 3 cytoplasmic domain
Family IPR001717 Anion exchange protein
Family IPR002977 Anion exchange protein 1
Family IPR003020 Bicarbonate transporter, eukaryotic
Homologous_superfamily IPR016152 Phosphotransferase/anion transporter
Domain Details Per Protein
Protein Length Anion exchange, conserved site Anion exchange protein Anion exchange protein 1 Band 3 cytoplasmic domain Bicarbonate transporter, C-terminal Bicarbonate transporter, eukaryotic Phosphotransferase/anion transporter
UniProtKB:D1FTM8 851
UniProtKB:F8W2B8 212
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-slc4a1b polyclonal Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations