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Gene

p2ry12

ID
ZDB-GENE-110208-4
Name
purinergic receptor P2Y12
Symbol
p2ry12 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Acts upstream of or within microglial cell activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Mazzolini et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With p2ry12 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
platelet-type bleeding disorder 8 Alliance Bleeding disorder, platelet-type, 8 609821
Associated With p2ry12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR005394 P2Y12 purinoceptor
Domain Details Per Protein
Protein Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like P2Y12 purinoceptor
UniProtKB:E7F2G6 345
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations