Gene
parapinopsina
- ID
- ZDB-GENE-101129-1
- Name
- parapinopsin a
- Symbol
- parapinopsina Nomenclature History
- Previous Names
-
- parapinopsin-1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables G protein-coupled photoreceptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway and detection of light stimulus. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in several structures, including endocrine system; eye; gut; heart; and integument.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Wada et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3021 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0N9NUD7 | InterPro | 341 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
parapinopsina-201
(1)
|
Ensembl | 1,077 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Bell, G.R.R., Rincón, E., Akdoğan, E., Collins, S.R. (2021) Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing. Nature communications. 12:6148
- Shen, B., Wada, S., Nishioka, H., Nagata, T., Kawano-Yamashita, E., Koyanagi, M., Terakita, A. (2021) Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish. Zoological letters. 7:1
- Wada, S., Kawano-Yamashita, E., Sugihara, T., Tamotsu, S., Koyanagi, M., Terakita, A. (2021) Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey. BMC Biology. 19:188
- Steindal, I.A.F., Whitmore, D. (2020) Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity. Frontiers in Physiology. 11:1002
- Wada, S., Shen, B., Kawano-Yamashita, E., Nagata, T., Hibi, M., Tamotsu, S., Koyanagi, M., Terakita, A. (2018) Color opponency with a single kind of bistable opsin in the zebrafish pineal organ. Proceedings of the National Academy of Sciences of the United States of America. 115(44):11310-11315
- Davies, W.I., Tamai, T.K., Zheng, L., Fu, J.K., Rihel, J., Foster, R.G., Whitmore, D., Hankins, M.W. (2015) An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome research. 25(11):1666-79
- Kawano-Yamashita, E., Koyanagi, M., Wada, S., Tsukamoto, H., Nagata, T., Terakita, A. (2015) Activation of Transducin by Bistable Pigment Parapinopsin in the Pineal Organ of Lower Vertebrates. PLoS One. 10:e0141280
- Koyanagi, M., Wada, S., Kawano-Yamashita, E., Hara, Y., Kuraku, S., Kosaka, S., Kawakami, K., Tamotsu, S., Tsukamoto, H., Shichida, Y., Terakita, A. (2015) Diversification of non-visual photopigment parapinopsin in spectral sensitivity for diverse pineal functions. BMC Biology. 13:73
- Shiraki, T., Kojima, D., and Fukada, Y. (2010) Light-induced body color change in developing zebrafish. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 9(11):1498-1504
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