ZFIN is now using GRCz12tu for Genomic Data
Gene
hecw2b
- ID
- ZDB-GENE-101001-3
- Name
- HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b
- Symbol
- hecw2b Nomenclature History
- Previous Names
-
- nedl2b (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in visual epilepsy. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia, seizures, and absent language | 617268 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Domain | IPR032348 | E3 ubiquitin-protein ligase HECW1/2, N-terminal |
| Domain | IPR037795 | E3 ubiquitin-protein ligase HECW, C2 domain |
| Domain | IPR040524 | E3 ubiquitin-protein ligase HECW1, helical box domain |
| Family | IPR050409 | E3 ubiquitin-protein ligase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | E3 ubiquitin-protein ligase | E3 ubiquitin-protein ligase HECW1/2, N-terminal | E3 ubiquitin-protein ligase HECW1, helical box domain | E3 ubiquitin-protein ligase HECW, C2 domain | HECT domain | HECT, E3 ligase catalytic domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RSA0 | InterPro | 1472 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hecw2b-201
(1)
|
Ensembl | 1,350 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance