Gene
nfatc3b
- ID
- ZDB-GENE-100922-25
- Name
- nuclear factor of activated T cells 3b
- Symbol
- nfatc3b Nomenclature History
- Previous Names
-
- si:ch73-46g7.3
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NFATC3 (nuclear factor of activated T cells 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lin et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa974 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24732 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31116 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44358 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Family | IPR008366 | Nuclear factor of activated T cells (NFAT) |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Nuclear factor of activated T cells (NFAT) | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3APB5 | InterPro | 924 | ||||||||
| UniProtKB:F1QMI6 | InterPro | 923 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfatc3b-201
(1)
|
Ensembl | 3,663 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-46G7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921732 (1) | 3358 nt | ||
| Genomic | GenBank:CU855766 (1) | 109038 nt | ||
| Polypeptide | UniProtKB:A0A8M3APB5 (1) | 924 aa |
- Lin, S.J., Chiang, M.C., Shih, H.Y., Hsu, L.S., Yeh, T.H., Huang, Y.C., Lin, C.Y., Cheng, Y.C. (2017) Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade. Biochimica et biophysica acta. 1864(3):463-474
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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