ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnc3a
- ID
- ZDB-GENE-100901-1
- Name
- potassium voltage-gated channel, Shaw-related subfamily, member 3a
- Symbol
- kcnc3a Nomenclature History
- Previous Names
-
- kv3.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables voltage-gated potassium channel activity. Acts upstream of or within motor neuron axon guidance. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in several cellular components, including dendrite membrane; neuronal cell body membrane; and synaptic membrane. Is expressed in Purkinje cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia type 13 | Alliance | Spinocerebellar ataxia 13 | 605259 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Family | IPR003968 | Potassium channel, voltage dependent, Kv |
| Family | IPR003974 | Potassium channel, voltage dependent, Kv3 |
| Family | IPR028325 | Voltage-gated potassium channel |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv3 | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily | Voltage-gated potassium channel |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PW22 | InterPro | 626 | ||||||||
| UniProtKB:A0A8M9P777 | InterPro | 666 | ||||||||
| UniProtKB:A0A8M3AQN6 | InterPro | 636 | ||||||||
| UniProtKB:A0A8M3B8C3 | InterPro | 609 | ||||||||
| UniProtKB:E1AZA4 | InterPro | 642 | ||||||||
| UniProtKB:E1AZA5 | InterPro | 659 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnc3a-201
(1)
|
Ensembl | 2,320 nt | ||
| mRNA |
kcnc3a-202
(1)
|
Ensembl | 1,929 nt | ||
| mRNA |
kcnc3a-203
(1)
|
Ensembl | 2,080 nt | ||
| mRNA |
kcnc3a-204
(1)
|
Ensembl | 1,980 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-kcnc3a | Rabbit |
|
1 |
Plasmids
No data available
- Genome Browsers