Gene
cd40lg
- ID
- ZDB-GENE-100727-1
- Name
- CD40 ligand
- Symbol
- cd40lg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits CD40 receptor binding activity. Involved in positive regulation of immunoglobulin production. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune hypersensitivity disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Is expressed in gill; integument; liver; and pleuroperitoneal region. Orthologous to human CD40LG (CD40 ligand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| CD40 ligand deficiency | Alliance | Immunodeficiency, X-linked, with hyper-IgM | 308230 |
| X-linked hyper IgM syndrome | Alliance | Immunodeficiency, X-linked, with hyper-IgM | 308230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tumour necrosis factor, conserved site | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|
|
UniProtKB:B8YI05
|
260 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cd40lg-201
(1)
|
Ensembl | 1,791 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cd40lg | IgG | Rabbit |
|
2 |
Plasmids
No data available