Gene
mypn
- ID
- ZDB-GENE-100721-5
- Name
- myopalladin
- Symbol
- mypn Nomenclature History
- Previous Names
-
- wu:fc17a02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Is expressed in heart. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1KK and nemaline myopathy 11. Orthologous to human MYPN (myopalladin).
- Genome Resources
-
- Alliance (1)
- Gene:571695 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1KK | Alliance | Cardiomyopathy, dilated, 1KK | 615248 |
| dilated cardiomyopathy 1KK | Alliance | Cardiomyopathy, familial restrictive, 4 | 615248 |
| dilated cardiomyopathy 1KK | Alliance | Cardiomyopathy, hypertrophic, 22 | 615248 |
| nemaline myopathy 11 | Alliance | Congenital myopathy 24 | 617336 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UTI8 | InterPro | 1904 | ||||||
| UniProtKB:A0AB13A3L9 | InterPro | 1877 | ||||||
| UniProtKB:A0AB13A9B6 | InterPro | 1904 | ||||||
| UniProtKB:A0AB32T1J7 | InterPro | 1865 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001365297 (1) | 6724 nt | ||
| Genomic | GenBank:CU929278 (1) | 106600 nt | ||
| Polypeptide | UniProtKB:A0A8N7UTI8 (1) | 1904 aa |
- Comparative Orthology
- Alliance
- Han, C.R., Wang, H., Hoffmann, V., Zerfas, P., Kruhlak, M., Cheng, S.Y. (2020) Thyroid hormone receptor α mutations cause heart defects in zebrafish. Thyroid : official journal of the American Thyroid Association. 31(2):315-326
- Hsieh, F.C., Lu, Y.F., Liau, I., Chen, C.C., Cheng, C.M., Hsiao, C.D., Hwang, S.L. (2018) Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Scientific Reports. 8:7856
- Pasquier, J., Cabau, C., Nguyen, T., Jouanno, E., Severac, D., Braasch, I., Journot, L., Pontarotti, P., Klopp, C., Postlethwait, J.H., Guiguen, Y., Bobe, J. (2016) Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. BMC Genomics. 17:368
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
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