Gene
ptprea
- ID
- ZDB-GENE-100714-1
- Name
- protein tyrosine phosphatase receptor type Ea
- Symbol
- ptprea Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in plasma membrane. Orthologous to human PTPRE (protein tyrosine phosphatase receptor type E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2648 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5604 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9616 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9880 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38906 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Family | IPR016336 | Receptor tyrosine-protein phosphatase, alpha/epsilon-type |
| Family | IPR050348 | Protein-Tyrosine Phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein-Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Receptor tyrosine-protein phosphatase, alpha/epsilon-type | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QJB7 | InterPro | 711 | |||||||
| UniProtKB:A0A8M9PXB4 | InterPro | 710 | |||||||
| UniProtKB:E7EZG7 | InterPro | 681 | |||||||
| UniProtKB:A0A8M1RFA7 | InterPro | 634 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptprea-201
(1)
|
Ensembl | 5,539 nt | ||
| mRNA |
ptprea-202
(1)
|
Ensembl | 2,091 nt | ||
| mRNA |
ptprea-203
(1)
|
Ensembl | 2,402 nt | ||
| mRNA |
ptprea-204
(1)
|
Ensembl | 5,454 nt | ||
| mRNA |
ptprea-205
(1)
|
Ensembl | 2,483 nt | ||
| mRNA |
ptprea-206
(1)
|
Ensembl | 5,391 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-30F1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480416 (1) | 5983 nt | ||
| Genomic | GenBank:BX321882 (2) | 187475 nt | ||
| Polypeptide | UniProtKB:A0A8M9QJB7 (1) | 711 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | PTPRE | 10 | Amino acid sequence comparison (2) |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
- van Eekelen, M., Runtuwene, V., Overvoorde, J., and den Hertog, J. (2010) RPTPalpha and PTPepsilon Signaling via Fyn/Yes and RhoA is Essential for Zebrafish Convergence and Extension Cell Movements during Gastrulation. Developmental Biology. 340(2):626-639
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