Gene
aldh1l1
- ID
- ZDB-GENE-100519-4
- Name
- aldehyde dehydrogenase 1 family, member L1
- Symbol
- aldh1l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables formyltetrahydrofolate dehydrogenase activity and hydrolase activity. Acts upstream of or within several processes, including embryonic morphogenesis; neural crest cell migration; and neuromast deposition. Predicted to be located in cytosol. Is expressed in several structures, including cardiovascular system; digestive system; fin; hematopoietic system; and nervous system. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Chang et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12463 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15821 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa18221 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20698 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20699 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20700 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40691 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-aldh1l1 | N/A | Chang et al., 2014 |
| MO2-aldh1l1 | N/A | Chang et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001555 | Phosphoribosylglycinamide formyltransferase, active site |
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR002376 | Formyl transferase, N-terminal |
| Domain | IPR005793 | Formyl transferase, C-terminal |
| Domain | IPR009081 | Phosphopantetheine binding ACP domain |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Family | IPR011407 | 10-formyltetrahydrofolate dehydrogenase |
| Homologous_superfamily | IPR011034 | Formyl transferase-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
| Homologous_superfamily | IPR016163 | Aldehyde dehydrogenase, C-terminal |
| Homologous_superfamily | IPR036477 | Formyl transferase, N-terminal domain superfamily |
| Homologous_superfamily | IPR036736 | ACP-like superfamily |
| Homologous_superfamily | IPR037022 | Formyl transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 10-formyltetrahydrofolate dehydrogenase | ACP-like superfamily | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase | Formyl transferase, C-terminal | Formyl transferase, C-terminal domain superfamily | Formyl transferase-like, C-terminal domain superfamily | Formyl transferase, N-terminal | Formyl transferase, N-terminal domain superfamily | Phosphopantetheine binding ACP domain | Phosphoribosylglycinamide formyltransferase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E3NZ06 | InterPro PDB | 903 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh1l1-201
(1)
|
Ensembl | 5,863 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-156N14 | ||
| Contained in | Fosmid | ZFOS-2506A4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001198772 (1) | 2770 nt | ||
| Genomic | GenBank:BX004829 (1) | 231581 nt | ||
| Polypeptide | UniProtKB:E3NZ06 (1) | 903 aa |
- Grinberg, L., Dabbah Assadi, F., Baum, G., Zemel, R., Tur-Kaspa, R., Shochat, C., Karasik, D., Karpuj, M.V. (2023) Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model. Nutrients. 15(6):
- Shaikh, A., Roy, H. (2023) Folate deprivation induced neuroinflammation impairs cognition. Neuroscience letters. 807:137264
- Zhai, W., Wang, Z., Ye, C., Ke, L., Wang, H., Liu, H. (2023) IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish. International Journal of Molecular Sciences. 24(24):
- Hsiao, T.H., Lee, G.H., Chang, Y.S., Chen, B.H., Fu, T.F. (2021) The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Frontiers in cell and developmental biology. 9:702969
- Umans, R.A., Pollock, C., Mills, W.A., Clark, K.C., Pan, Y.A., Sontheimer, H. (2021) Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development. Frontiers in cell and developmental biology. 9:654338
- Chen, J., Poskanzer, K.E., Freeman, M.R., Monk, K.R. (2020) Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. 23(10):1297-1306
- Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
- Solanki, A.K., Kondkar, A.A., Fogerty, J., Su, Y., Kim, S.H., Lipschutz, J.H., Nihalani, D., Perkins, B.D., Lobo, G.P. (2020) A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish. Cells. 9(5):
- Lodd, E., Wiggenhauser, L.M., Morgenstern, J., Fleming, T.H., Poschet, G., Büttner, M., Tabler, C.T., Wohlfart, D.P., Nawroth, P.P., Kroll, J. (2019) The combination of loss of glyoxalase1 and obesity results in hyperglycemia. JCI insight. 4(12):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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