Gene
ndst2b
- ID
- ZDB-GENE-100430-2
- Name
- N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b
- Symbol
- ndst2b Nomenclature History
- Previous Names
-
- ndst2
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable deacetylase activity and heparan sulfate N-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, chain elongation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in alar plate midbrain region; brain; midbrain neural rod; optic tectum; and rhombomere. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Filipek-Górniok et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9179 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9867 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13344 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27994 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31891 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35347 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Heparan sulfate sulfotransferase | Heparan sulphate-N-deacetylase, deacetylase domain | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7F995 | InterPro | 893 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ndst2b-201
(1)
|
Ensembl | 3,669 nt | ||
| mRNA |
ndst2b-202
(1)
|
Ensembl | 3,345 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-127M5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-153F13 | ||
| Contained in | BAC | CH211-237E12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480391 (1) | 5663 nt | ||
| Genomic | GenBank:CR759788 | 197075 nt | ||
| Polypeptide | UniProtKB:E7F995 (2) | 893 aa |
- Comparative Orthology
- Alliance
- Anderson, R.A., Oyarbide, U. (2022) Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation. Gene expression patterns : GEP. 47:119300
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Filipek-Górniok, B., Carlsson, P., Haitina, T., Habicher, J., Ledin, J., Kjellén, L. (2015) The Ndst Gene Family in Zebrafish: Role of Ndst1b in Pharyngeal Arch Formation. PLoS One. 10:e0119040
- Harfouche, R., Hentschel, D.M., Piecewicz, S., Basu, S., Print, C., Eavarone, D., Kiziltepe, T., Sasisekharan, R., and Sengupta, S. (2009) Glycome and Transcriptome Regulation of Vasculogenesis. Circulation. 120(19):1883-1892
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