Gene

depdc5

ID
ZDB-GENE-091204-356
Name
DEP domain containing 5, GATOR1 subcomplex subunit
Symbol
depdc5 Nomenclature History
Previous Names
  • si:dkey-106l3.5
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Is predicted to contribute to GTPase activator activity. Involved in regulation of neuronal action potential and swimming behavior. Predicted to localize to GATOR1 complex and lysosomal membrane. Is expressed in central nervous system and notochord. Used to study focal epilepsy. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With depdc5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epilepsy, familial focal, with variable foci 1 604364
Associated With depdc5 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000591 DEP domain
Family IPR027244 Vacuolar membrane-associated protein Iml1
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length DEP domain Vacuolar membrane-associated protein Iml1 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:E7EXM8 1603
UniProtKB:F1RCR1 266
UniProtKB:F1QKZ0 149
UniProtKB:E9QH20 1568
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations