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ZIRC
ZFIN ID: ZDB-GENE-091204-274
Gene Name: G protein-coupled receptor kinase 5
Gene Symbol: grk5    Nomenclature History

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Previous Name: si:dkey-171l20.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and G protein-coupled receptor kinase activity. Involved in heart development; positive regulation of Wnt signaling pathway; and regulation of heart contraction. Human ortholog(s) of this gene implicated in essential hypertension. Is expressed in brain; cardiovascular system; and otic vesicle. Orthologous to human GRK4 (G protein-coupled receptor kinase 4).
Genome Resources: Alliance (1),  Gene:560806 (1),  Ensembl(GRCz11):ENSDARG00000032801 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-grk5 N/A 3
MO2-grk5 N/A 1
MO3-grk5 N/A 1
DISEASE ASSOCIATED WITH grk5 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH grk5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart development (more)
Molecular Function ATP binding (more)
GO Terms (all 13)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA grk5-201 (1)    Ensembl 642
grk5-202 (1)    Ensembl 2460
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM grk5 No data available
MARKER RELATIONSHIPS
grk5 Contained in: [BAC] CH73-171B11 (1) (order this), DKEY-171L20 (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001173503 (1) 2460 bp
Genomic GenBank:CT027796 (1) 87354 bp
Select Tool
Polypeptide UniProtKB:F1RAR9 (1) 588 aa
Sequence Clusters UniGene:18531 (1)
Sequence Information (all 18)
ORTHOLOGY for grk5 ( Chr: 10 )
CITATIONS (15)