Gene
fosl1b
- ID
- ZDB-GENE-091204-259
- Name
- FOS like 1, AP-1 transcription factor subunit b
- Symbol
- fosl1b Nomenclature History
- Previous Names
-
- si:dkey-17e16.12
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including blastodisc; epidermis; female organism; hatching gland; and male organism. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FOSL1 (FOS like 1, AP-1 transcription factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Kubra et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AP-1 transcription factor | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:E9QHS1 | InterPro | 200 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fosl1b-201
(1)
|
Ensembl | 928 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-17E16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009295436 (1) | |||
| Genomic | GenBank:CR388166 (1) | 220882 nt | ||
| Polypeptide | UniProtKB:E9QHS1 (1) | 200 aa |
- Fleischhauer, L., López-Delgado, A.C., Geurtzen, K., Knopf, F. (2023) Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling. Frontiers in endocrinology. 14:11223511122351
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Maili, L., Tandon, B., Yuan, Q., Menezes, S., Chiu, F., Hashmi, S.S., Letra, A., Eisenhoffer, G.T., Hecht, J.T. (2023) Disruption of fos causes craniofacial anomalies in developing zebrafish. Frontiers in cell and developmental biology. 11:11418931141893
- Kubra, K., Gaddu, G.K., Liongue, C., Heidary, S., Ward, A.C., Dhillon, A.S., Basheer, F. (2022) Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. International Journal of Molecular Sciences. 23(17)
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Jiang, L., Romero-Carvajal, A., Haug, J.S., Seidel, C.W., Piotrowski, T. (2014) Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 111:E1383-92
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