Gene

cables2a

ID

ZDB-GENE-091118-58

Name

Cdk5 and Abl enzyme substrate 2a

Symbol

cables2a Nomenclature History

Previous Names

si:dkey-202m22.8

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to act upstream of or within regulation of cell cycle. Orthologous to human CABLES2 (Cdk5 and Abl enzyme substrate 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa39418	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44018	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With cables2a Human Ortholog

No data available

Associated With cables2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006671	Cyclin, N-terminal
Domain	IPR013763	Cyclin-like domain
Family	IPR012388	CDK5 and ABL1 enzyme substrate 1/2
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	CDK5 and ABL1 enzyme substrate 1/2	Cyclin-like domain	Cyclin-like superfamily	Cyclin, N-terminal
UniProtKB:A0A8M2B986	InterPro	479
UniProtKB:A0A8M9Q830	InterPro	505

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 23

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cables2a-201 (1) Ensembl	Ensembl		1,945 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-202M22	AL845357	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_001919790 (1)	2927 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL845357 (1)	221012 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M9Q830 (1)	505 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	CABLES2	20	Ensembl:ENSG00000149679 Gene:81928 HGNC:16143 OMIM:618772	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Cables2	2	Ensembl:ENSMUSG00000038990 Gene:252966 MGI:2182335	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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