Gene
lhx2a
- ID
- ZDB-GENE-091118-109
- Name
- LIM homeobox 2a
- Symbol
- lhx2a Nomenclature History
- Previous Names
-
- si:dkey-261o10.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in neural tube; olfactory epithelium; olfactory placode; and peripheral olfactory organ. Orthologous to human LHX2 (LIM homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Miyasaka et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1R0M6 | InterPro | 327 | |||||
| UniProtKB:E9QBI8 | InterPro | 328 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-10lhx2a:EGFP) |
|
| 1 | (7) | |
| Tg(-10lhx2a:GAP-EYFP) |
|
| 1 | (9) | |
| Tg(lhx2a:syp-GFP) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261O10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001159586 (1) | 1351 nt | ||
| Genomic | GenBank:FP016184 (1) | 93410 nt | ||
| Polypeptide | UniProtKB:E9QBI8 (1) | 328 aa |
- O'Quin, K.E., Yoshizawa, M., Doshi, P., and Jeffery, W.R. (2013) Quantitative Genetic Analysis of Retinal Degeneration in the Blind Cavefish Astyanax mexicanus. PLoS One. 8(2):e57281
- Miyasaka, N., Morimoto, K., Tsubokawa, T., Higashijima, S., Okamoto, H., and Yoshihara, Y. (2009) From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(15):4756-4767
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