Gene
cobl
- ID
- ZDB-GENE-091020-11
- Name
- cordon-bleu WH2 repeat protein
- Symbol
- cobl Nomenclature History
- Previous Names
-
- im:7136115
- si:ch211-207g17.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable actin monomer binding activity. Acts upstream of or within cilium assembly and embryonic organ morphogenesis. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and ruffle. Is expressed in several structures, including Kupffer's vesicle; midbrain hindbrain boundary neural rod; nervous system; pronephros; and trunk. Orthologous to human COBL (cordon-bleu WH2 repeat protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136115 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019886Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019887Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13808 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22756 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36044 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cobl | N/A | Ravanelli et al., 2011 |
| MO2-cobl | N/A | Ravanelli et al., 2011 |
| MO3-cobl | N/A | Schuler et al., 2013 |
| MO4-cobl | N/A | Schuler et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cordon-bleu, ubiquitin-like domain | Protein cordon-bleu-like | WH2 domain |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9NZ94 | InterPro | 1354 | |||
| UniProtKB:A0A2R8QQI2 | InterPro | 1328 | |||
| UniProtKB:T1ECS5 | InterPro | 1327 | |||
| UniProtKB:E7F568 | InterPro | 1343 | |||
| UniProtKB:A0A8M1RKQ2 | InterPro | 1354 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207G17 | ||
| Encodes | EST | IMAGE:7136115 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001289913 (1) | 5448 nt | ||
| Genomic | GenBank:BX537113 (1) | 206307 nt | ||
| Polypeptide | UniProtKB:A0A2R8QQ65 (1) | 1369 aa |
- Comparative Orthology
- Alliance
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Khodiyar, V.K., Howe, D., Talmud, P.J., Breckenridge, R., Lovering, R.C. (2013) From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development.. F1000 Research. 2:1-17
- Schuler, S., Hauptmann, J., Perner, B., Kessels, M.M., Englert, C., and Qualmann, B. (2013) Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. Journal of Cell Science. 126(1):196-208
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ravanelli, A.M., and Klingensmith, J. (2011) The Actin Nucleator Cordon-bleu is Required for Development of Motile Cilia in Zebrafish. Developmental Biology. 350(1):101-111
- Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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