Gene
macc1
- ID
- ZDB-GENE-091006-3
- Name
- MET transcriptional regulator MACC1
- Symbol
- macc1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within embryonic cranial skeleton morphogenesis. Predicted to be active in cytoplasm. Is expressed in eye; midbrain hindbrain boundary; otic vesicle; stomodeum; and telencephalon. Orthologous to human MACC1 (MET transcriptional regulator MACC1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Melvin et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Melvin et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb693 | Allele with one delins | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-macc1 | Zebrafish Nomenclature Committee | |
| MO1-macc1 | N/A | Melvin et al., 2013 |
| MO2-macc1 | N/A | Melvin et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000906 | ZU5 domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ZU5 domain |
|---|---|---|---|
| UniProtKB:E7FG38 | InterPro | 853 | |
| UniProtKB:A0AB32T3T1 | InterPro | 857 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-10F11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199766 (1) | 3606 nt | ||
| Genomic | GenBank:BX005389 (2) | 93050 nt | ||
| Polypeptide | UniProtKB:A0AB32T3T1 (1) | 857 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
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