Gene
slc2a1b
- ID
- ZDB-GENE-090915-1
- Name
- solute carrier family 2 member 1b
- Symbol
- slc2a1b Nomenclature History
- Previous Names
-
- si:dkey-92f12.1
- zglut1a (2)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables D-glucose transmembrane transporter activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including bone tissue; heart; liver; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in childhood absence epilepsy; glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dystonia 9 | Alliance | Dystonia 9 | 601042 |
| glucose transporter type 1 deficiency syndrome 1 | Alliance | GLUT1 deficiency syndrome 1, infantile onset, severe | 606777 |
| glucose transporter type 1 deficiency syndrome 2 | Alliance | GLUT1 deficiency syndrome 2, childhood onset | 612126 |
| obsolete idiopathic generalized epilepsy 12 | Alliance | {Epilepsy, idiopathic generalized, susceptibility to, 12} | 614847 |
| Stomatin-deficient cryohydrocytosis with neurologic defects | 608885 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR005829 | Sugar transporter, conserved site |
| Domain | IPR020846 | Major facilitator superfamily domain |
| Family | IPR003663 | Sugar/inositol transporter |
| Family | IPR005828 | Major facilitator, sugar transporter-like |
| Family | IPR045263 | Glucose transporter GLUT |
| Homologous_superfamily | IPR036259 | MFS transporter superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucose transporter GLUT | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R0Q1 | InterPro | 489 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a1b-201
(1)
|
Ensembl | 1,823 nt | ||
| mRNA |
slc2a1b-202
(1)
|
Ensembl | 1,371 nt | ||
| mRNA |
slc2a1b-203
(1)
|
Ensembl | 1,392 nt |
Interactions and Pathways
No data available
Plasmids
No data available