Gene

slc2a1b

ID

ZDB-GENE-090915-1

Name

solute carrier family 2 member 1b

Symbol

slc2a1b Nomenclature History

Previous Names

si:dkey-92f12.1
zglut1a (2)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Exhibits D-glucose transmembrane transporter activity. Involved in sprouting angiogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk. Orthologous to human SLC2A1 (solute carrier family 2 member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc2a1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
childhood onset GLUT1 deficiency syndrome 2	Alliance	GLUT1 deficiency syndrome 2, childhood onset	612126
dystonia 9	Alliance	Dystonia 9	601042
idiopathic generalized epilepsy 12	Alliance	{Epilepsy, idiopathic generalized, susceptibility to, 12}	614847
		GLUT1 deficiency syndrome 1, infantile onset, severe	606777
		Stomatin-deficient cryohydrocytosis with neurologic defects	608885

Associated With slc2a1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR005829	Sugar transporter, conserved site
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR003663	Sugar/inositol transporter
Family	IPR005828	Major facilitator, sugar transporter-like
Homologous_superfamily	IPR036259	MFS transporter superfamily

Domain Details Per Protein

Protein	Length	Major facilitator, sugar transporter-like	Major facilitator superfamily domain	MFS transporter superfamily	Sugar/inositol transporter	Sugar transporter, conserved site
UniProtKB:A0A2R8Q853 InterPro	463
UniProtKB:F1R0Q1 InterPro	489
UniProtKB:A0A2R8QGQ5 InterPro	456

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	slc2a1b-201 (1) Ensembl	1823 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations