Gene

tdp1

ID
ZDB-GENE-090909-1
Name
tyrosyl-DNA phosphodiesterase 1
Symbol
tdp1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair and single strand break repair. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Zaksauskaite et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Zaksauskaite et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tdp1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 607250
Associated With tdp1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR010347 Tyrosyl-DNA phosphodiesterase I
Domain Details Per Protein
Protein Length Tyrosyl-DNA phosphodiesterase I
UniProtKB:F8W5U2 615
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA tdp1-201 (1) Havana 2349 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations