grin2ba

ID

ZDB-GENE-090821-2

Name

glutamate ionotropic receptor NMDA type subunit 2B a

Symbol

grin2ba Nomenclature History

Previous Names

NR2B.1 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable NMDA glutamate receptor activity. Predicted to be involved in ionotropic glutamate receptor signaling pathway and monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Is expressed in head; optic tectum; ventral hypothalamic zone; and ventral thalamus nucleus. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zoodsma et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grin2ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 6	Alliance	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	613970
developmental and epileptic encephalopathy 27	Alliance	Developmental and epileptic encephalopathy 27	616139

Associated With grin2ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR018884	Glutamate [NMDA] receptor, epsilon subunit, C-terminal
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q0I1	InterPro	1417
UniProtKB:A0AB32TID9	InterPro	1170
UniProtKB:A0AC58IZX5	InterPro	1606
UniProtKB:A0AC58IZX9	InterPro	1606
UniProtKB:A0AC58IZY1	InterPro	1170
UniProtKB:A0AC58IZY4	InterPro	1606
UniProtKB:A0AC58IZY5	InterPro	1170
UniProtKB:A0AC58IZY7	InterPro	1170
UniProtKB:A0AC58IZY8	InterPro	1606
UniProtKB:A0AC58IZY9	InterPro	1170
UniProtKB:A0AC58IZZ0	InterPro	1170
UniProtKB:A0AC58IZZ3	InterPro	1170
UniProtKB:A0AC58IZZ5	InterPro	1170
UniProtKB:A0AC58J000	InterPro	1170