Gene
chrm4b
- ID
- ZDB-GENE-090410-7
- Name
- cholinergic receptor, muscarinic 4b
- Symbol
- chrm4b Nomenclature History
- Previous Names
-
- DrM4B (1)
- si:ch73-151m17.5
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled acetylcholine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-chrm4b | Thyme et al., 2019 | |
| CRISPR2-chrm4b | Thyme et al., 2019 | |
| CRISPR3-chrm4b | Thyme et al., 2019 | |
| CRISPR4-chrm4b | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Muscarinic acetylcholine receptor family |
|---|---|---|---|---|---|
| UniProtKB:X1WE62 | InterPro | 451 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch73-151m17.5-201
(1)
|
Ensembl | 2,058 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-151M17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001343935 (1) | 1693 nt | ||
| Genomic | GenBank:CU181898 (1) | 122601 nt | ||
| Polypeptide | UniProtKB:X1WE62 (1) | 451 aa |
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2018) Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. eNeuro. 5(5):
- Nuckels, R.J., Forstner, M.R., Capalbo-Pitts, E.L., and García, D.M. (2011) Developmental expression of muscarinic receptors in the eyes of zebrafish. Brain research. 1405:85-94
- Seo, J.S., Kim, M.S., Park, E.M., Ahn, S.J., Kim, N.Y., Jung, S.H., Kim, J.W., Lee, H.H., and Chung, J.K. (2009) Cloning and characterization of muscarinic receptor genes from the nile tilapia (Oreochromis niloticus). Molecules and cells. 27(3):383-390
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