Gene
htr1ab
- ID
- ZDB-GENE-090409-2
- Name
- 5-hydroxytryptamine (serotonin) receptor 1A b
- Symbol
- htr1ab Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Acts upstream of or within spinal cord motor neuron differentiation. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in brain; pharynx; retina; and spinal cord. Human ortholog(s) of this gene implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Barreiro-Iglesias et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nv1167 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-htr1ab | N/A | Barreiro-Iglesias et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vesicoureteral reflux | Alliance | ?Periodic fever, menstrual cycle dependent | 614674 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:C0ITL9 | InterPro | 403 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htr1ab-201
(1)
|
Ensembl | 1,212 nt | ||
| mRNA |
htr1ab-202
(1)
|
Ensembl | 1,438 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-263M18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-246J23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145766 (1) | 1212 nt | ||
| Genomic | GenBank:BX530056 (1) | 235804 nt | ||
| Polypeptide | UniProtKB:C0ITL9 (1) | 403 aa |
- Soren, K., Bollikanda, R.K., Das, T., Patel, S., Gnaneshwari, K., Malakar, P., Kumar, A., Kantevari, S., Chakravarty, S. (2024) Development of CRID3-Based Anti-inflammatory Agents to Ameliorate Chronic Hypoxia-Induced Memory Impairment in Zebrafish Models. ACS Chemical Neuroscience. 15(13):2504-2519
- Tea, M., Pan, Y.K., Lister, J.G.R., Perry, S.F., Gilmour, K.M. (2024) Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 210(5):785-799
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Li, Y., Zhang, L., Mao, M., He, L., Wang, T., Pan, Y., Zhao, X., Li, Z., Mu, X., Qian, Y., Qiu, J. (2023) Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. iScience. 26:106744106744
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Horzmann, K.A., Lin, L.F., Taslakjian, B., Yuan, C., Freeman, J.L. (2022) Anxiety-related behavior and associated brain transcriptome and epigenome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Chemosphere. 308(Pt 3):136431
- Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144
- Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
- Kumar, N., Zhao, H.N., Awoyemi, O., Kolodziej, E.P., Crago, J. (2021) Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System. Environmental science & technology. 55(5):3070-3080
- Yang, H., Liang, X., Zhao, Y., Gu, X., Mao, Z., Zeng, Q., Chen, H., Martyniuk, C.J. (2021) Molecular and behavioral responses of zebrafish embryos/larvae after sertraline exposure. Ecotoxicology and environmental safety. 208:111700
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