ZFIN is now using GRCz12tu for Genomic Data
Gene
scn1bb
- ID
- ZDB-GENE-090408-1
- Name
- sodium channel, voltage-gated, type I, beta b
- Symbol
- scn1bb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables voltage-gated sodium channel activity. Acts upstream of or within cell adhesion and sodium ion transport. Located in myelin sheath and neuronal cell body. Is expressed in nervous system; otic vesicle; and pronephros. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Fein et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Brugada syndrome 5 | Alliance | Brugada syndrome 5 | 612838 |
| Brugada syndrome 5 | Alliance | Cardiac conduction defect, nonspecific | 612838 |
| developmental and epileptic encephalopathy 52 | Alliance | Developmental and epileptic encephalopathy 52 | 617350 |
| familial atrial fibrillation | Alliance | Atrial fibrillation, familial, 13 | 615377 |
| generalized epilepsy with febrile seizures plus 1 | Alliance | Generalized epilepsy with febrile seizures plus, type 1 | 604233 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Sodium channel subunit beta-1/beta-3 |
|---|---|---|---|---|---|---|---|
| UniProtKB:B3F0A3 | InterPro | 222 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
scn1bb-201
(1)
|
Ensembl | 1,854 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-scn1bb | polyclonal | Rabbit |
|
Open Biosystems
|
2 |
Plasmids
No data available
- Genome Browsers