Gene
cd40
- ID
- ZDB-GENE-090313-95
- Name
- CD40 molecule, TNF receptor superfamily member 5
- Symbol
- cd40 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables CD154 receptor binding activity. Acts upstream of or within TRIF-dependent toll-like receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gong et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency with hyper IgM type 3 | Alliance | Immunodeficiency with hyper-IgM, type 3 | 606843 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TNFR/NGFR cysteine-rich region | Tumor Necrosis Factor Receptor Superfamily Member 5 |
|---|---|---|---|
|
UniProtKB:B8X730
|
286 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-231H20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145246 (1) | 4484 nt | ||
| Genomic | GenBank:CR381544 (1) | 146827 nt | ||
| Polypeptide | UniProtKB:B8X730 (1) | 286 aa |
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Cheng, Y., Cao, P., Geng, C., Chu, X., Li, Y., Cui, J. (2022) The adenosine A (2A) receptor antagonist SCH58261 protects photoreceptors by inhibiting microglial activation and the inflammatory response. International Immunopharmacology. 112:109245
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Xiao, X., Liu, Z., Su, G., Liu, H., Yin, W., Guan, Y., Jing, S., Du, L., Li, F., Li, N., Yang, P. (2022) A novel uveitis model induced by lipopolysaccharide in zebrafish. Frontiers in immunology. 13:10428491042849
- Su, N., Hu, C.B., Shao, T., Jin, C.Y., Li, H., Ji, J.F., Qin, L.L., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2021) Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection. Fish and shellfish Immunology reports. 2:100038100038
- Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832
- Duan, J., Liang, S., Feng, L., Yu, Y., Sun, Z. (2018) Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro. International Journal of Nanomedicine. 13:7303-7318
- Liu, G.P., Xiang, L.X., Shao, T., Lin, A.F., Shao, J.Z. (2018) Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model. Developmental and comparative immunology. 84:353-360
- Tandberg, J., Lagos, L., Ropstad, E., Smistad, G., Hiorth, M., Winther-Larsen, H.C. (2018) The Use of Chitosan-Coated Membrane Vesicles for Immunization Against Salmonid Rickettsial Septicemia in an Adult Zebrafish Model. Zebrafish. 15(4):372-381
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