Gene

fbxw7

ID

ZDB-GENE-090313-79

Name

F-box and WD repeat domain containing 7

Symbol

fbxw7 Nomenclature History

Previous Names

si:ch211-208n2.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Involved in angiogenesis; negative regulation of myelination; and regulation of signal transduction. Is expressed in glioblast (sensu Vertebrata); neural tube; neuroblast (sensu Vertebrata); spinal cord; and trunk. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fbxw7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental delay, hypotonia, and impaired language	Alliance	Developmental delay, hypotonia, and impaired language	620012

Associated With fbxw7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001810	F-box domain
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036047	F-box-like domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	F-box domain	F-box-like domain superfamily	G-protein beta WD-40 repeat	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:B7ZDC8 InterPro
UniProtKB:B8A474 InterPro
UniProtKB:F1RCB5 InterPro
UniProtKB:A0A8M9Q490 InterPro	834
UniProtKB:A0A8M9Q0J4 InterPro	761
UniProtKB:A0A8M9PRD0 InterPro	606
UniProtKB:A0A8M9Q8H7 InterPro	605
UniProtKB:A0A8M2BI81 InterPro	545
UniProtKB:A0A8M9PIU0 InterPro	835

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	fbxw7-201 (1) Ensembl	Ensembl		3,312 nt	Select Tool ZFIN BLAST
mRNA	fbxw7-202 (1) Ensembl	Ensembl		2,256 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fbxw7	polyclonal	fbxw7		Rabbit	WB	Millipore	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations