Gene

prss12

ID
ZDB-GENE-090313-45
Name
serine protease 12
Symbol
prss12 Nomenclature History
Previous Names
  • si:ch211-152j23.2
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Anderson et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la021031TgTransgenic insertionUnknownUnknownDNA
sa14034Allele with one point mutationUnknownPremature StopENU
zko389aAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-prss12China Zebrafish Resource Center (CZRC)
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Human Disease
Associated With prss12 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 1 Alliance Intellectual developmental disorder, autosomal recessive 1 249500
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Associated With prss12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR001190 SRCR domain
Domain IPR001254 Serine proteases, trypsin domain
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Domain Details Per Protein
Protein Length Kringle Kringle, conserved site Kringle-like fold Kringle superfamily Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, serine active site SRCR domain SRCR-like domain superfamily
UniProtKB:A0A8M1QHD3 818
UniProtKB:A0A8M9PPR7 818
UniProtKB:A0A8M9Q8F7 660
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prss12-201 (1) Ensembl 2,451 nt
mRNA prss12-202 (1) Ensembl 5,200 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-152J23ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPRSS124
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MousePrss123
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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