Gene
palb2
- ID
- ZDB-GENE-090313-43
- Name
- partner and localizer of BRCA2
- Symbol
- palb2 Nomenclature History
- Previous Names
-
- fancn (1)
- Fanconi anemia, complementation group N
- si:ch211-14k19.9
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be active in nucleoplasm. Is expressed in brain; eye; immature eye; lens; and pectoral fin fold. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; female breast cancer; hereditary breast ovarian cancer syndrome; and pancreatic cancer. Orthologous to human PALB2 (partner and localizer of BRCA2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Titus et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hg62 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| hg63 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| kh27 | Allele with one deletion | Unknown | Inframe Deletion | CRISPR | |
| sa19424 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19425 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19426 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19427 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umo80 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| zko182a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-palb2 | (3) | |
| CRISPR2-palb2 | Shin et al., 2021 | |
| CRISPR3-palb2 | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group N | Alliance | Fanconi anemia, complementation group N | 610832 |
| {Breast-ovarian cancer, familial, susceptibility to, 5} | 620442 | ||
| {Pancreatic cancer, susceptibility to, 3} | 613348 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR031920 | Partner and localiser of BRCA2, WD40 domain |
| Family | IPR042417 | Partner and localizer of BRCA2 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Length | Partner and localiser of BRCA2, WD40 domain | Partner and localizer of BRCA2 | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QKC3
|
1294 | ||||
|
UniProtKB:A0A8M9P7S0
|
1275 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-14K19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001919731 (1) | 4162 nt | ||
| Genomic | GenBank:BX004779 (1) | 196036 nt | ||
| Polypeptide | UniProtKB:A0A8M1QKC3 (1) | 1294 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Ramanagoudr-Bhojappa, R., Carrington, B., Ramaswami, M., Bishop, K., Robbins, G.M., Jones, M., Harper, U., Frederickson, S.C., Kimble, D.C., Sood, R., Chandrasekharappa, S.C. (2018) Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. PLoS Genetics. 14:e1007821
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Titus, T.A., Yan, Y.L., Wilson, C., Starks, A.M., Frohnmayer, J.D., Canestro, C., Rodriguez-Mari, A., He, X., and Postlethwait, J.H. (2009) The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics. Mutation research. 668(1-2):117-132
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